Caspase-1 Colorimetric Assay Kit (TBS2040)
$289.00
Apoptosis plays a fundamental role in many normal biological processes as well as in several disease states. Apoptosis can be induced by various stimuli that all produce the same end result: systematic and orderly cell death. The inflammasome is a large multiprotein complex whose assembly leads to the activation of caspase-1, which promotes the maturation of proinflammatory cytokines interleukin-1β (IL-1β) and IL-18.
| SKU | Stock | SIZE (test) | Price | Quantity | ||
|---|---|---|---|---|---|---|
| TBS2040 | Yes | 100 Tests | $289.00 |
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Description
Apoptosis plays a fundamental role in many normal biological processes as well as in several disease states. Apoptosis can be induced by various stimuli that all produce the same end result: systematic and orderly cell death.
The inflammasome is a large multiprotein complex whose assembly leads to the activation of caspase-1, which promotes the maturation of proinflammatory cytokines: interleukin-1β (IL-1β) and IL-18.
The TriboTM Caspase-1 Colorimetric Assay Kits provide a simple and convenient means for assaying the activity of caspases that recognize the sequence YVAD. The assay is based on spectrophotometric detection of the chromophore p- nitroaniline (pNA) after cleavage from the labeled substrate YVAD-pNA. The pNA light emission can be quantified using a spectrophotometer or a microtiter plate reader at 400- or 405-nm. Comparison of the absorbance of pNA from an apoptotic sample with an uninduced control allows the determination of the fold increase in caspase-1 activity.
APPLICATIONS
- Apoptosis
- Drug screening
- Growth factors
- Cytotoxicity
RELATED PRODUCTS
- Resazurin Cell Viability (TBS2001)
- LDH Cytotoxicity Assay (TBS2002)
- MTT Cell Viability Assay (TBS 2003)
- MTS Cell Viability Assay (TBS2004)
- Catalase Assay (TBS2006)
Additional information
| SIZE (test) | 100 Tests |
|---|
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