Why Some People Are More Susceptible to SARS-CoV-2?Tribioscience
As COVID19 continues to rage across the US and around the world, scientists and physicians continue to be perplexed by why some younger patients with no underlying conditions succumb to SARS-CoV-2. In addition, these victims are disproportionately male.
Now a research article published in Science by Bastard et al. may have provided some clues to the mystery. Bastard’s research shows that about 14% of critically ill COVID19 patients have autoantibodies against Type I interferons, namely IFN α2 and IFN ω. A portion of these autoantibody carriers also have autoantibodies against IFN γ, GM-CSF, TNF α, IL-6, IL-10, IL-12, IL-17, and IL-22. Men are disproportionately represented due to the high possibility that the production of autoantibodies is driven by mutations on the X chromosome.
Link to Bastard et al. article.
FAST Human IFN ω ELISA Kit
FAST Human IFN α2 ELISA Kit