Dinaciclib, CDK inhibitor (TBI4845)

Description

Product Details

Formal Name: 2-[(2S)-1-[3-Ethyl-7-[(1-oxidopyridin-1-ium-3-yl)methylamino]pyrazolo[1,5-a]pyrimidin-5-yl]piperidin-2-yl]ethanol

Alternate Name: SCH 727965

Molecular Formula: C₂₁H₂₈N₆O₂

Formula Weight: 396.5

CAS Number: 779353-01-4

Purity: >98%

Formulation: Powder

Solubility: Soluble in DMSO (> 25 mg/ml)

Storage: -20°C

Stability: ≥ 2 years

Applications

CDK inhibitor

Functions

Potent and selective inhibitor of cyclin-dependent kinases CDK1, CDK2, CDK5, and CDK9 (IC₅₀s respectively: 3 nM, 1 nM, 1 nM, and 4 nM). Active across multiple human cancer cell lines and in mouse xenograft models.

Application Procedures

First dissolved in DMSO (> 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.

Research use only.

Additional information

Datasheet:

TBI4845_Dinaciclib_datasheet

MSDS:

TBI4845_Dinaciclib_MSDS

Research use only.