DPTIP, Neutral sphingomyelinase 2 inhibitor (TBI4394)

Description

Product Details

Formal Name: 2,6-Dimethoxy-4-(4-phenyl-5-thiophen-2-yl-1H-imidazol-2-yl)phenol

Molecular Formula: C₂₁H₁₈N₂O₃S

Formula Weight: 378.4

CAS Number: 351353-48-5

Purity: >98%

Formulation: Powder

Solubility: Soluble in DMSO (> 25 mg/ml)

Storage: -20°C

Stability: ≥ 2 years

Applications

Neutral sphingomyelinase 2 inhibitor

Functions

Selective, potent (IC₅₀ = 30 nM), and brain penetrant inhibitor of neutral sphingomyelinase 2 (nSMase2). In a mouse model of brain injury, it inhibited IL-1ß-induced astrocyte-derived extracellular vesicle release which reduced cytokine upregulation and attenuation of infiltration of immune cells to the brain leading to decreased inflammation. Displayed potent antiviral activity against Zika and West Nile viruses (EC50 Vero cells: 0.26 µM and 1.56 µM respectively). Acted synergistically with enzalutamide to significantly suppress cell proliferation, colony formation, and migration of metastatic castration resistant prostate cancer cells. It also reduced tumor size and weight in a prostate cancer mouse model.

Application Procedures

First dissolved in Soluble in DMSO (> 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.

Research use only.

Additional information

Datasheet:

TBI4394_DPTIP_datasheet

MSDS:

TBI4394_DPTIP_MSDS

Research use only.