ZJ43, Potent inhibitor of glutamate carboxypeptidases II and III (TBI3904)
$171.00 – $666.00
Potent inhibitor of glutamate carboxypeptidases II and III
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI3904-5MG | Yes | 5 MG | $171.00 | |||
TBI3904-25MG | Yes | 25 MG | $666.00 |
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Description
Product Details
Formal Name: N-[[[(1S)-1-Carboxy-3-methylbutyl]amino]carbonyl]-L-glutamic acid
Molecular Formula: C12H20N2O7
Formula Weight: 304.30
CAS Number: 723331-20-2
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to at least 25 mg/ml) or in water (up to at least 25 mg/ml)
Storage: -20°C
Stability: ≥ 1 year.
Applications
Potent inhibitor of glutamate carboxypeptidases II and III
Functions
Potent inhibitor of glutamate carboxypeptidase II (Ki = 0.8 nM) and III (Ki = 23 nM). Potently inhibits (IC50 = 2.4 nM) the ability of glutamate carboxypeptidase II to hydrolyze the neurotransmitter N-acetylaspartylglutamate (NAAG), resulting in an increase in synaptic levels of group II mGluRs. Peripherally administered ZJ43 increased the activation of mGluR3 by NAAG released from peripheral sensory neurites resulting in analgesia. ZJ43 has also shown efficacy in other inflammatory pain models.
Application Procedures
First dissolved in DMSO (up to at least 25 mg/ml) or in water (up to at least 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or distilled water may be stored at -20° for up to 2 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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