SI-2, Potent inhibitor of SRC-3 (steroid receptor coactivator-3) (TBI3903)
$126.00 – $414.00
Potent inhibitor of SRC-3 (steroid receptor coactivator-3)
SKU | Stock | SIZE (mg) | Price | Quantity | ||
---|---|---|---|---|---|---|
TBI3903-5MG | Yes | 5 MG | $126.00 | |||
TBI3903-25MG | Yes | 25 MG | $414.00 |
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Description
Product Details
Formal Name: 1-Methyl-N-[(E)-1-pyridin-2-ylethylideneamino]benzimidazole-2-amine
Molecular Formula: C15H15N5
Formula Weight: 265.30
CAS Number: 380537-35-9
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 20 mg/ml)
Storage: -20°C
Stability: ≥ 1 year.
Applications
Potent inhibitor of SRC-3 (steroid receptor coactivator-3)
Functions
Potent inhibitor of steroid receptor coactivator-3 (SRC-3). Blocks growth of MDA-MB-468 cells (IC50 = 3.4 nM) without effecting normal cells.1 It significantly inhibited breast cancer cell growth in an orthotopic MDA-MD-468 mouse model. Treatment of MCF-7 or triple negative MDA-MB-231 cells with SI-2 resulted in inhibition of proliferation and breast cancer stem cell (CSC) tumorsphere formation. CSC markers CD44+/CD24-/1o and aldehyde dehydrogenase (ALDH) were also reduced indicating that SI-2 can selectively interfere with the TIC/CSC state in breast cancer cells.
Application Procedures
First dissolved in DMSO (up to 20 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20° for up to 1 month.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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