Defactinib, Potent FAK inhibitor (TBI4828)
$117.00 – $387.00
Potent FAK inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI4828-5MG | Yes | 5 MG | $117.00 | |||
TBI4828-25MG | Yes | 25 MG | $387.00 |
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Description
Product Details
Formal Name: N-Methyl-4-[[4-[[3-[methyl(methylsulfonyl)amino]pyrazin-2-yl]methylamino]-5-(trifluoromethyl)pyrimidin-2-yl]aminl]benzamide
Molecular Formula: C20H21F3N8O3S
Formula Weight: 510.50
CAS Number: 1073154-85-4
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to at least 25 mg/ml)
Storage: -20°C
Stability: ≥ 1 year.
Applications
Potent FAK inhibitor
Functions
Defactinib (1073154-85-4) is a potent inhibitor of FAK (IC50 = 0.6nM) and Pyk2 (IC50 = 0.6nM). It is active in vivo (EC50 = 26nM). FAK inhibition prevents tumor invasion and dissemination rather than tumor size reduction. Defactinib has been shown to preferentially target cancer stem cells in a mouse xenograft model of triple negative breast cancer. It is in multiple clinical trials for various cancers and in shows synergistic activity when used in combination with checkpoint immunotherapy.
Application Procedures
First dissolved in DMSO (up to at least 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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