YM-155, Survivin inhibitor (TBI1473)
$104.00 – $396.00
Survivin inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI1473-5MG | Yes | 5 MG | $104.00 | |||
TBI1473-25MG | Yes | 25 MG | $396.00 |
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Description
Product Details
Formal Name: 1-(2-methoxyethyl)-2-methyl-4,9-dioxo-3-(pyrazin-2-ylmethyl)-4,9-dihydro-1H-naphtho[2,3-d]imidazol-3-ium bromide
Alternate Names: Sepantronium bromide
Molecular Formula: C20H19BrN4O3
Formula Weight: 443.30
CAS Number: 781661-94-7
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 25 mg/ml).
Storage: -20°C
Stability: ≥ 2 years.
Applications
Survivin inhibitor
Functions
A novel small molecule survivin suppressant. YM-155 suppresses expression of survivin (a member of the IAP family) and induced apoptosis in human tumor cell lines at 10 nmol/L with little effect on other IAP or Bcl-2 family members. Overcomes erlotinib resistance in EGFR mutation-positive non-small cell lung cancer. Induces DNA damage. Induces an autophagy-dependent cell death in adenoid cystic carcinoma cells.
Application Procedures
First dissolved in DMSO (up to 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20° for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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