BO-264, TACC3 inhibitor (TBI4685)
$117.00 – $432.00
TACC3 inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI4685-5MG | Yes | 5 MG | $117.00 | |||
TBI4685-25MG | Yes | 25 MG | $432.00 |
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Description
Product Details
Formal Name: 3-(4-Methoxyphenyl)-N-(2-morpholin-4-ylpyrimidin-4-yl)-1,2-oxazol-5-amine
Molecular Formula: C18H19N5O3
Formula Weight: 353.40
CAS Number: 2408648-20-2
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to at least 25 mg/ml)
Storage: -20°C
Stability: ≥ 1 year.
Applications
TACC3 inhibitor
Functions
BO-264 is a potent (IC50 = 188 nM) inhibitor of transforming acidic coiled-coil 3 (TACC3), an important protein involved in microtubule stability and centrosome integrity. TACC3 is frequently upregulated in a broad range of cancers. BO-264 displayed significant anticancer activity in greater than 90% of cell lines in the NCI-60 human cancer cell line panel. Active in vivo in mice injected with JIMT-1 and EMT6 breast cancer cells as well as mouse colon cancer xenografts HCT-116 and CT-26.
Application Procedures
First dissolved in DMSO (up to at least 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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