CB-839, Glutaminase Inhibitor (TBI4556)
$99.00 – $315.00
Glutaminase Inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI4556-5MG | Yes | 5 MG | $99.00 | |||
TBI4556-25MG | Yes | 25 MG | $315.00 |
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Description
Product Details
Formal Name: 2-(Pyridin-2-yl)-N-(5-(4-(6-(2-(3-(trifluoromethoxy)phenyl)acetamido)pyridazin-3-yl)butyl)-1,3,4-thiadiazol-2-yl)acetamide
Alternate Names: Telaglenastat
Molecular Formula: C26H24F3N7O3S
Formula Weight: 571.60
CAS Number: 1439399-58-2
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (20 mg/ml)
Storage: -20°C
Stability: ≥ 1 year.
Applications
Glutaminase Inhibitor
Functions
Potent and noncompetitive inhibitor of both glutaminase GLS splice variants (KGA and GAC, IC50 ~ 25 nM), but not GLS2. It limits the entry of glutamine derivates into the TCA cycle, starves tumor cells of glutamine, and ablates stem-like cells in GLS-overexpressing glioblastoma cells. Effective in a variety of cancer models, including triple-negative breast cancer and squamous cell carcinoma.
Application Procedures
First dissolved in DMSO (20 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20° for up to 2 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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