BG45, HDAC3 selective inhibitor (TBI5638)
$108.00 – $432.00
HDAC3 selective inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
---|---|---|---|---|---|---|
TBI5638-5MG | Yes | 5 MG | $108.00 | |||
TBI5638-25MG | Yes | 25 MG | $432.00 |
- Description
- Terms
- Additional information
- Documents
- Reviews (0)
Description
Product Details
Formal Name: N-(2-Aminophenyl)-2-pyrazinecarboxamide
Molecular Formula: C11H10N4O
Formula Weight: 214.20
CAS Number: 926259-99-6
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (45 mg/ml)
Storage: -20°C
Stability: ≥ 2 years.
Applications
HDAC3 selective inhibitor
Functions
A potent and selective HDAC3 inhibitor (IC50 = 289 nM), IC50s for HDAC1, 2 and 6 = 2, 2.2 and >20 µM respectively. Inhibits tumor growth in a mouse xenograft model of human multiple myeloma. Downregulates expression of DNA methyltransferase 1. Increases expression of synaptic proteins in exogenous Aβ-treated cells and mice. Rescues synaptic damage and neuron loss in APP-transfected cells (15 µM) and APP/PS1 mice (30 mg/kg).
Application Procedures
First dissolved in DMSO (45 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 2 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
---|
Be the first to review “BG45, HDAC3 selective inhibitor (TBI5638)”
You must be logged in to post a review.
Reviews
There are no reviews yet.