Ac-YVAD-pNA, caspase-1/4 (TBP0139)

Description

Ac‑YVAD‑pNA is a chromogenic peptide substrate specifically designed to probe caspase‑1 and caspase‑4 activity. Its p‑nitroaniline (pNA) moiety exhibits a strong absorbance peak near 405 nm, providing a straightforward, quantitative readout of caspase‑1/-4 activity in vitro. Ac‑YVAD‑pNA is commonly used to investigate inflammasome activation, pyroptosis, and related inflammatory signaling pathways.

Product Details

Formal Name: N-acetyl-L-tyrosyl-L-valyl-L-alanyl-N-(4-nitrophenyl)-L-α-asparagine, trifluoroacetate salt

Alternate Names: N-Acetyl-Tyr-Val-Ala-Asp-p-Nitroanilide; Caspase-1 substrate (Chromogenic)

Molecular Formula: C₂₉H₃₆N₆O₁₀ • XCF₃COOH

Formula Weight: 628.6

CAS Number: 149231-66-3

Purity: ≥95%

Formulation: powder

Storage: -20°C

Stability: >4 years

Solubility: DMF: 50 mg/ml; DMSO: 25 mg/ml; PBS (pH 7.2): 2 mg/ml

Research use only.

Additional information

Datasheet:

TBP0139-Ac-YVAD-pNA_datasheet

MSDS:

TBP0139_Ac-YVAD-pNA_MSDS

Research use only.