XIB4035, GFRa1 agonist (TBI1486)
$108.00 – $432.00
GFRa1 agonist
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI1486-5MG | Yes | 5 MG | $108.00 | |||
TBI1486-25MG | Yes | 25 MG | $432.00 |
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Description
Product Details
Formal Name: (E)-N4-(7-chloro-2-(2-chlorostyryl)quinolin-4-yl)-N1,N1-diethylpentane-1,4-diamine, 3(H3PO4)
Molecular Formula: C26H31Cl2N3 · 3(H3PO4)
Formula Weight: 750.45
CAS Number: 10023-54-8
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 25 mg/ml with warming).
Storage: RT
Stability: ≥ 2 years.
Applications
GFRa1 agonist
Functions
A novel small molecule thought to be an agonist at the glial cell line-derived neurotrophic factor (GDNF) family receptor α-1 GFRα-1. It inhibits radiolabeled GDNF binding in Neuro-2A cells in a concentration dependent manner IC50=10.4 μM. Like GDNF, it induced Ret autophosphorylation and promoted neurite outgrowth in Neuro-2A cells. Recent studies indicate that it enhances GFRα family receptor signaling in conjunction with ligand stimulation. Effective treatment for small-fiber neuropathy in mouse models of the disease. GDNF agonists may be a new class of Parkinson’s disease therapeutics.
Application Procedures
First dissolved in DMSO (up to 25 mg/ml with warming), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20° for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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