Indirubin-3′-monoxime, GSK-3b and CDK inhibitor (TBI1488)
$108.00 – $432.00
GSK-3b and CDK inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI1488-5MG | Yes | 5 MG | $108.00 | |||
TBI1488-25MG | Yes | 25 MG | $432.00 |
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Description
Product Details
Formal Name: 3-[1,3-Dihydro-3-(hydroxyimino-2H-indol-2-ylidene]-1,3-dihydro-2H-indol-2-one
Alternate Names: Indirubin-3’oxime
Molecular Formula: C16H11N3O2
Formula Weight: 277.29
CAS Number: 160807-49-8
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 6 mg/ml) or in Ethanol (up to 4 mg/ml).
Storage: -20°C
Stability: ≥ 1 year.
Applications
GSK-3b and CDK inhibitor
Functions
A potent GSK-3β inhibitor (IC50=22 nM). Also inhibits CDK1 (IC50=180 nM) and CDK5 (IC50=100 nM). Displays antimitotic properties and induces endoreplication following prophase arrest in HBL-100 cells. Possesses antiangiogenic activity. Attenuates β-amyloid-associated neuropathology in a mouse model of Alzheimer’s disease. Cell permeable.
Application Procedures
First dissolved in DMSO (up to 6 mg/ml) or in Ethanol (up to 4 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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