TGN-020, Aquaporin 4 blocker (TBI1546)
$135.00 – $540.00
Aquaporin 4 blocker
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI1546-10MG | Yes | 10 MG | $135.00 | |||
TBI1546-50MG | Yes | 50 MG | $540.00 |
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Description
Product Details
Formal Name: N-1,3,4-thiadiazol-2-yl-3-pyridinecarboxamide
Molecular Formula: C8H6N4OS
Formula Weight: 206.22
CAS Number: 51987-99-6
Purity: >98%
Formulation: Powder
Solubility: Soluble in DMSO (up to 10 mg/ml with warming)
Storage: Room temperature
Stability: ≥ 2 years.
Applications
Aquaporin 4 blocker
Functions
Aquaporin 4 channel blocker, IC50 = 3.1 μM. Reduces ischemic cerebral edema in a mouse model of focal cerebral ischemia using MRI. Increases regional cerebral blood flow as determined in wild-type and AQP-4 knockout mice. Reduces brain edema when administered after onset of ischemia in rat models.
Application Procedures
First dissolved in DMSO (up to 10 mg/ml with warming), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.
Additional information
SIZE (mg) | 10 MG, 50 MG |
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