Compound 147 (AA147), ATF6 activator; ER proteostasis (TBI3973)
$126.00 – $495.00
ATF6 activator; ER proteostasis
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI3973-10MG | Yes | 10 MG | $126.00 | |||
TBI3973-50MG | Yes | 50 MG | $495.00 |
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Description
Product Details
Formal Name: N-(2-hydroxy-5-methylphenyl)-3-phenylpropanamide
Molecular Formula: C16H17NO2
Formula Weight: 255.3
CAS Number: 393121-74-9
Purity: >98%
Formulation: Powder
Solubility: Soluble in DMSO (up to at least 25 mg/ml) or in Ethanol (up to 25 mg/ml)
Storage: -20°C
Stability: ≥ 2 years.
Applications
ATF6 activator; ER proteostasis
Functions
Compound 147 is a preferential activator of the ER stress sensing protein ATF6. It was able to selectively reduce secretion and extracellular aggregation of destabilized amyloidogenic variants of TTR and LC proteins. Compound 147-dependent ATF6 activation proceeds via metabolic activation to a reactive electrophile that selectively modifies ER proteins including multiple protein disulfide isomerases. Compound 147 suppressed pluripotency and promoted human stem cell differentiation toward a mesodermal lineage via ER expansion. It protected the heart against ischemia/reperfusion (I/R) injury in a mouse model of acute myocardial infarction in an ATF6-dependent manner. Brain, kidney, and liver tissue was also protected from I/R damage and impaired proteostasis. Compound 147 reduced infection of multiple strains of dengue and Zika viruses in an ATF6-independent manner.
Application Procedures
First dissolved in DMSO (up to at least 25 mg/ml) or in Ethanol (up to 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Additional information
SIZE (mg) | 10 MG, 50 MG |
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