SW033291, 15-PGDH inhibitor (TBI4888)

Description

Product Details

Formal Name: 4-Butylsulfinyl-4-phenyl-6-thiophen-2-ylthieno[2,3-b]pyridin-3-amine

Molecular Formula: C₂₁H₂₀N₂OS₃

Formula Weight: 412.6

CAS Number: 459147-39-8

Purity: >98%

Formulation: Powder

Solubility: Soluble in DMSO (up to 25 mg/ml)

Storage: -20°C

Stability: ≥ 2 years

Applications

15-PGDH inhibitor

Functions

Inhibitor of 15-hydroxyprostaglandin dehydrogenase (IC₅₀ = 1.5 nM) that increases prostaglandin E2 levels in bone marrow and other tissues by inhibiting in vivo degradation of PGE2. It accelerated neutrophil recovery, regeneration of platelets and red blood cells, and expanded the numbers of more primitive bone marrow SKL cells in bone marrow transplants. Also stimulated colon epithelial regeneration in a mouse model of ulcerative colitis. It increased bone formation in mice via PGE₂ activation of EP4. Enhanced myogenic differentiation and myotube formation in repairing muscle defects in mice. It reduced the severity of pulmonary fibrotic lesions and extracellular matrix remodeling and improved pulmonary function in bleomycin-treated mice. It also prevented hepatic ischemia-reperfusion injury in mice. Mitigates oxidative damage, suppresses neuroinflammation, and restores blood-brain barrier integrity in mouse models of Alzheimer’s disease and traumatic brain injury. In addition to halting neurodegeneration, it also preserved cognitive function at levels indistinguishable from healthy controls.

Application Procedures

First dissolved in DMSO (up to 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 2 months.

Research use only.

Additional information

Datasheet:

TBI4888_SW033291_datasheet

MSDS:

TBI4888_SW033291_MSDS

Research use only.