SLU-PP-332, pan-ERR agonist/Exercise mimetic (TBI3948)

Description

Product Details

Formal Name: (E)-4-Hydroxy-N’-(naphthalen-2-ylmethylene)benzohydrazide

Alternate Names: 4-Hydroxybenzoic acid 2-(2-naphthalenylmethylene)hydrazide; SR9861

Molecular Formula: C₁₈H₁₄N₂O₂

Formula Weight: 290.3

CAS Number: 303760-60-3

Purity: >98%

Formulation: Powder

Solubility: Soluble in DMSO (up to at least 75 mg/ml)

Storage: -20°C

Stability: ≥ 2 years.

Applications

pan-ERR agonist/Exercise mimetic

Functions

Pan-agonist of the estrogen receptor-related receptors (EC₅₀’s cell-based cotransfection/reporter assay: ERRα = 98 nM, ERRß = 230 nM, ERRγ = 430 nM) with highest potency for ERRα.  SLU-PP-332 increased mitochondrial function and cellular respiration in a skeletal muscle cell line. It also increased fast oxidative skeletal muscle fibers (Type IIa) and exercise endurance in mice in an ERRα-specific manner. SLU-PP-332 activates an acute aerobic exercise genetic response via inducing the expression of DDIT4.

Application Procedures

First dissolved in DMSO (75 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.

Research use only.

Additional information

Datasheet:

TBI3948_SLU-PP-332_datasheet

MSDS:

TBI3948_SLU-PP-332_MSDS_2024

Research use only.