OSS-128167, SIRT6 inhibitor (TBI5197)

Description

Product Details

Formal Name: 5-(3-(Furan-2-carboxamido)benzamido)-2-hydroxybenzoic acid

Molecular Formula: C₁₉H₁₄N₂O₆

Formula Weight: 366.3

CAS Number: 887686-02-4

Purity: >98%

Formulation: Powder

Solubility: Soluble in DMSO (25 mg/ml); or Ethanol (25 mg/ml)

Storage: -20°C

Stability: ≥ 2 years.

Applications

SIRT6 inhibitor

Functions

OSS-128167 is an inhibitor of SIRT6 (IC₅₀=89 µM) showing selectivity over SIRT1 and SIRT2 (IC₅₀s=1,578 and 751 µM, respectively). In diffuse large B-cell lymphoma cells which overexpress SIRT6, treatment with OSS-128167 resulted in higher rates of apoptosis, arrested cell cycle progression and augmented sensitivity to chemotherapy. It exacerbates diabetic cardiomyopathy by aggravating inflammation and oxidative stress in a streptozotocin-induced diabetic mouse model and delays peripheral nerve recovery after injury by suppressing migration, phagocytosis and M2-polarization of macrophages. OSS-128167 promotes cell senescence and aging in myocardial H9c2 cells.

Application Procedures

First dissolved in DMSO (25 mg/ml) or Ethanol (25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.

Research use only.

Additional information

Datasheet:

TBI5197_OSS-128167_datasheet

MSDS:

TBI5197_OSS-128167_MSDS_2024

Research use only.