MreB Inhibitor A22, Disrupts bacterial actin cytoskeleton (TBI5275)

Description

Product Details

Formal Name: 2-(3,4-Dichloro-benzyl)-isothiourea, hydrochloride

Alternate Name: MreB Purturbing Compound A22

Molecular Formula: C₈H₈Cl₂N₂S • HCl

Formula Weight: 271.6

CAS Number: 22816-60-0

Purity: >98%

Formulation: Powder

Solubility: Soluble in Water (6 mg/ml); or DMSO (30 mg/ml)

Storage: -20°C

Stability: ≥ 2 years.

Applications

Disrupts bacterial actin cytoskeleton

Functions

Disrupts the actin cytoskeleton of bacteria causing defects in morphology and chromosome segregation. It is a competitive inhibitor of ATP binding to MreB and has the ability to disassemble the actin cytoskeleton in bacterial cells. It displays antibacterial activity against P. aeruginosa (among many others) including multidrug-resistant clinical isolates and points to MreB as a new target for antibacterial development. Significantly disrupts biofilm formation by interfering with the ability of bacterial cells to maintain shape and adherence to surfaces.

Application Procedures

First dissolved in Water (6 mg/ml) or DMSO (30 mg/ml), then diluted to aqueous buffer. Solutions in water or DMSO may be stored at -20°C for up to 3 months.

Research use only.

Additional information

Datasheet:

TBI5275_MreB Inhibitor A22_datasheet

MSDS:

TBI5275_MreB Inhibitor A22_MSDS

Research use only.