Moxidectin, Anthelmintic/YAP-TAZ blocker (TBI4436)

Description

Product Details

Formal Name: (1R,4S,4’E,5’S,6R,6’S,8R,10E,13R,14E,16E,20R,21R,24S)-21,24-dihydroxy-4′-methoxyimino-5′,11,13,22-tetramethyl-6′-[(E)-4-methylpent-2-en-2-yl]spiro[3,7,19-trioxatetracyclo[15.6.1.14,8.020,24]pentacosa-10,14,16,22-tetraene-6,2′-oxane]-2-one

Molecular Formula: C₃₇H₅₃NO₈

Formula Weight: 639.8

CAS Number: 113507-06-5

Purity: >98%

Formulation: Powder

Solubility: Soluble in DMSO (up to at least 25 mg/ml)

Storage: -20°C

Stability: ≥ 2 years

Applications

Anthelmintic/YAP-TAZ blocker

Functions

Macrocyclic lactone anthelmintic drug used in veterinary medicine for the treatment of various parasitic diseases. In 2018, It was approved for use in the treatment of river-blindness in humans. Moxidectin is also being investigated as a possible treatment for scabies in humans. Inhibited the proliferation of several glioblastoma multiforme (GBM) cell lines via induction of apoptosis. It inhibited the MEK-ERK pathway resulting in blocking of nuclear translocation and transcription of the YAP/TAZ-TEAD complex in GBM cells. It suppressed growth of GBM tumors by 90% in an intracranial tumor model.

Application Procedures

First dissolved in DMSO (up to at least 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.

Research use only.

Additional information

Datasheet:

TBI4436_Moxidectin_datasheet

MSDS:

TBI4436_Moxidectin_MSDS

Research use only.