Bempedoic acid, ATP citrate lyase inhibitor (TBI4114)
$81.00 – $225.00
ATP citrate lyase inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
---|---|---|---|---|---|---|
TBI4114-10MG | Yes | 10 MG | $81.00 | |||
TBI4114-50MG | Yes | 50 MG | $225.00 |
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Description
Product Details
Formal Name: 8-Hydroxy-2,2,14,14-tetramethylpentadecanedioic acid
Alternate Names: ESP 55016; ETC-1002
Molecular Formula: C19H36O5
Formula Weight: 344.5
CAS Number: 738606-46-7
Purity: >98%
Formulation: Powder
Solubility: Soluble in DMSO (up to at least 25 mg/ml)
Storage: -20°C
Stability: ≥ 2 years.
Applications
ATP citrate lyase inhibitor
Functions
Inhibitor of ATP citrate lyase (ACL) and activator of AMPK used in the treatment of hypercholesterolemia. In vivo, the active molecule is the CoA ester. Bempedoic acid requires activation by very long-chain acyl-CoA-synthetase (ACSVL1) – the absence of ACSVL1 in skeletal muscle provides a mechanistic basis for its use in statin-intolerant patients. LDL receptor upregulation, decreased LDL-C, and attenuation of atherosclerosis activities are independent of AMPK activation. It significantly cuts the risk of major cardiovascular events. Combination treatment of breast and pancreatic cancer cell lines with bempedoic acid and CDK4/6 inhibitors reduced cell growth and invasion. It displays anti-inflammatory activity possibly through both ACL inhibition and AMPK activation.
Application Procedures
First dissolved in DMSO (up to at least 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.
Additional information
SIZE (mg) | 10 MG, 50 MG |
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