CID1067700, Rab7 GTPase inhibitor (TBI5401)
$117.00 – $432.00
Rab7 GTPase inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI5401-5MG | Yes | 5 MG | $117.00 | |||
TBI5401-25MG | Yes | 25 MG | $432.00 |
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Description
Product Details
Formal Name: 2-[[(benzoylamino)thioxomethyl]amino]-4,7-dihydro-5,5-dimethyl-5H-thieno[2,3-c]pyran-3-carboxylic acid
Alternate Names: ML282
Molecular Formula: C18H18N2O4S2
Formula Weight: 390.50
CAS Number: 314042-01-8
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (40 mg/ml)
Storage: -20°C
Stability: ≥ 1 year.
Applications
Rab7 GTPase inhibitor
Functions
A specific competitive inhibitor of nucleotide binding to Rab7, an endosome-localized small GTPase. It interferes with the Rab7-RILP interaction, locking the GTPase in an inactive conformation. Impairs B cell class switching and plasma cell survival dampening, the pathogenic autoantibody response in lupus. Inhibits the Arf-like small GTPase Arl8b, blocking cellular egress of β-coronaviruses (SARS-CoV-2) which utilize a lysosomal exocytosis pathway.
Application Procedures
First dissolved in DMSO (40 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 2 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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