MBQ-167, Rac/Cdc42 inhibitor (TBI4434)
$135.00 – $477.00
Rac/Cdc42 inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI4434-5MG | Yes | 5 MG | $135.00 | |||
TBI4434-25MG | Yes | 25 MG | $477.00 |
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Description
Product Details
Formal Name: 1-(9-Ethyl-9H-carbazol-3-yl)-5-phenyl-1H-1,2,3-triazole; 9-Ethyl-3-(5-phenylcarbazol-1-yl)carbazole
Molecular Formula: C22H18N4
Formula Weight: 338.41
CAS Number: 2097938-73-1
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 25 mg/ml).
Storage: -20°C
Stability: ≥ 1 year.
Applications
Rac/Cdc42 inhibitor
Functions
Dual inhibitor of the Rho GTPases Rac (IC50 = 103 nM) and Cdc42 (IC50 = 78 nM). It inhibits breast cancer cell migration, viability, and mammosphere formation. MBQ-167 induced polarity loss resulting in 95% cell rounding and detachment from the substratum in metastatic MDA-MB-231 cells and was active in GFP-HER2-BM, MDA-MB-468, and Hs578t breast cancer cells as well as Mia-PaCa-2 pancreatic cancer cells, SKOV3 ovarian cancer cells, AGS and NCI-N87 gastric cancer cells, and SH-SY5Y neuroblastoma cells. Non-cancerous mammary epithelial MCF10A and epithelial breast cancer MCF-7 cells were resistant to MBQ-167. MBQ-167 inhibited viability and induced apoptosis in gefitinib and lapatinib resistant SKBR3 breast cancer cells. MBQ-167 inhibited triple negative breast cancer tumor growth and lung metastasis in a mouse model. Active in vivo.
Application Procedures
First dissolved in DMSO (up to 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 2 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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