CCG-4986, RGS4 inhibitor (TBI1431)
$108.00 – $396.00
RGS4 inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI1431-5MG | Yes | 5 MG | $108.00 | |||
TBI1431-25MG | Yes | 25 MG | $396.00 |
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Description
Product Details
Formal Name: Methyl-N-[(4-chlorophenyl)sulfonyl]-4-nitrobenzenesulfinimidoate
Molecular Formula: C13H11ClN2O5S2
Formula Weight: 374.80
CAS Number: 7134-19-2
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 60 mg/ml), or in Ethanol (up to 5 mg/ml with warming).
Storage: -20°C
Stability: ≥ 2 years.
Applications
RGS4 inhibitor
Functions
The first selective non-peptide inhibitor of the regulator of G protein signaling protein subtype RGS4. It covalently modifies RGS4 by inhibiting its interaction with Gα (IC50 = 3-5 µM) and suppressing GTPase activity. Intratympanic administration of CCG-4986 was shown to rescue cochlear injury and hearing loss induced by acoustic overexposure and represents a novel paradigm for the treatment of sensorineural hearing loss via pharmacological regulation of GPCR signaling. A novel tool for exploring the involvement of RGS4 in physiological processes.
Application Procedures
First dissolved in DMSO (up to 60 mg/ml), or in Ethanol (up to 5 mg/ml with warming), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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