BIX-01294, Histone methyl transferase inhibitor(TBI1335)
$108.00 – $432.00
Histone methyl transferase inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI1335-5MG | Yes | 5 MG | $108.00 | |||
TBI1335-25MG | Yes | 25 MG | $432.00 |
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Description
Product Details
Formal Name: 2-(Hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimethoxy-N-[1-(phenylmethyl)-4-piperidinyl]-4-quinazolinamine trihydrochloride
Molecular Formula: C28H38N6O2
Formula Weight: 600.02
CAS Number: 935693-62-2
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 50 mg/ml), or in Water (up to 50 mg/ml).
Storage: RT
Stability: ≥ 1 year.
Applications
Histone methyl transferase inhibitor
Functions
BIX-01294 is a selective inhibitor of G9a histone methyltransferase (G9aHMTase; IC50 = 1.7 µM) as well as GLP HMTase (IC50 = 38 µM) leading to a decrease in H3K9me2(histone H3 lysine 9 methylation) in vitro. BIX-01294 facilitates the reactivation of pluripotency genes and induces passive demethylation, thus promoting reprogramming. BIX-01294, in combination with BAY K8644 (a calcium channel agonist), was found to improve reprogramming efficiencies of Oct4-Klf4-(OK)-infected neural progenitor cells.
Application Procedures
First dissolved in DMSO (up to 50 mg/ml), or in Water (up to 50 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or distilled water may be stored at -20° for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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