V-9302, Glutamine transport inhibitor (TBI4245)
$108.00 – $405.00
Glutamine transport inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI4245-5MG | Yes | 5 MG | $108.00 | |||
TBI4245-25MG | Yes | 25 MG | $405.00 |
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Description
Product Details
Formal Name: (2S)-2-Amino-4-[bis[[2-[(3-methylphenyl)methoxy]phenyl]methyl]amino]butanoic acid
Molecular Formula: C34H38N2O4
Formula Weight: 538.69
CAS Number: 1855871-76-9
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to at least 70 mg/ml)
Storage: -20°C
Stability: ≥ 2 years.
Applications
Glutamine transport inhibitor
Functions
Selective inhibitor of the alanine-serine-cysteine transporter 2 (ASCT2 or SLC1A5; IC50 = 9.0 µM rat and 9.6 µM human). It inhibited the uptake of both glutamine and possibly other amino acids in human cancer cells and reduced in vitro viability by at least 20% in more than half of 29 cancer cell lines screened. V-9302 decreased mTOR activity, elevated autophagy, and increased oxidative stress in multiple animal cancer models.
Application Procedures
First dissolved in DMSO (up to at least 70 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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