Tubastatin A HCl, HDAC6 inhibitor (TBI4530)
$99.00 – $351.00
HDAC6 inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI4530-5MG | Yes | 5 MG | $99.00 | |||
TBI4530-25MG | Yes | 25 MG | $351.00 |
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Description
Product Details
Formal Name: N-Hydroxy-4-[(2-methyl-3,4-dihydro-1H-pyrido[4,3-b]indol-5-yl)methyl]benzamide hydrochloride
Molecular Formula: C20H22N3O2 · HCl
Formula Weight: 371.86
CAS Number: 1310693-92-5
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 50 mg/ml).
Storage: -20°C
Stability: ≥ 2 years.
Applications
HDAC6 inhibitor
Functions
Potent and selective histone deacetylase 6 (HDAC6) inhibitor, IC50=15 nM (>1000-fold selective against other HDACs and 60-fold for HDAC8). Inhibits TNF-α (IC50=272 nM) and IL-6 (IC50=712 nM) in LPS-stimulated human macrophages and displays anti-inflammatory activity in animal models. Improves survival in animal models of sepsis. Improves cognition in Alzheimers disease transgenic mice. Cell permeable.
Application Procedures
First dissolved in DMSO (up to 50 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or distilled water may be stored at -20° for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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