Kenpaullone, GSK-3beta, CDK, KLF4 inhibitor (TBI3028)
$144.00 – $432.00
GSK-3beta, CDK, KLF4 inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI3028-5MG | Yes | 5 MG | $144.00 | |||
TBI3028-25MG | Yes | 25 MG | $432.00 |
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Description
Product Details
Formal Name: 9-Bromo-7,12-dihydro-indolo[3,2-d][1]benzazepin-6(5H)-one
Alternate Names: NSC-664704
Molecular Formula: C16H11BrN2O
Formula Weight: 327.20
CAS Number: 142273-20-9
Purity: >98%
Formulation: powder
Solubility: Soluble in DSMO (up to 40 mg/ml)
Storage: RT
Stability: ≥ 2 years.
Applications
GSK-3beta, CDK, KLF4 inhibitor
Functions
Kenpaullone inhibits GSK-3β (IC50=0.23 µM) as well as several cyclin-dependent kinases (CDKs), IC50=0.4, 0.68 and 0.85 µM for cdk1, cdk2 and cdk5 respectively. Induces pluripotent stem cells from somatic cells and increases direct neural conversion of human fibroblasts when used with other small molecules. Inhibits Kruppel-Like Factor 4 (KLF4) reducing autoimmune arthritis in the collagen-induced arthritis mouse model.
Application Procedures
First dissolved in DSMO (up to 40 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 1 month.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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