Human Nicotinamide N-Methyltransferase / NNMT Recombinant Protein, Bioactive (TBP0002)
$263.00 – $3,800.00
SKU | Stock | SIZE | Price | Quantity | ||
---|---|---|---|---|---|---|
TBP0002-20UG | Yes | 20 µg | $263.00 | |||
TBP0002-100UG | Yes | 100 µg | $860.00 | |||
TBP0002-500UG | Yes | 500 µg | $3,800.00 |
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Description
NNMT (Nicotinamide N-methyltransferase) belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. It is predominantly expressed in the liver, and a lower expression is seen in the kidney, lung, skeletal muscle, placenta, and heart. NNMT catalyzes the N-methylation of nicotinamide and other pyridines to form pyridinium ions. This activity is important for the biotransformation of many drugs and xenobiotic compounds. Recombinant human NNMT protein, fused to His-tag at N-terminus, was expressed in E. coli, and purified by using chromatography. This enzyme is validated for NNMT activity application.
Product Details
Expression System: E. coli.
Domain: 1-264aa.
UniProt No: P40261.
Alternative Names: Nicotinamide N-methyltransferase/ NNMT.
Product Specification
Molecular Weight: 37.7 kDa (284aa) confirmed by MALDI-TOF
Concentration: 1mg/ml (determined by Bradford assay).
Formulation: Liquid in 20 mM Tris-HCl buffer (pH 8.0) containing 20% glycerol, No DTT.
Purity: > 95% by SDS-PAGE.
Tag: His-Tag.
Biological Activity: Specific activity is > 100nmol/min/mg, and is defined as the amount of enzyme that transfers 1.0nmole of methyl group per minute at 37℃.
Storage Condition: Store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Applications
- Enzyme Activity, and protein assay by SDS-PAGE
Additional information
SIZE | 100 µg, 20 µg, 500 µg |
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Datasheet:
TBP0002-NNMT Recombinant Protein data sheet_V01_2023
MSDS:
TBP0002_Human Nicotinamide N-Methyltransferase NNMT Recombinant Protein Safety Data Sheet
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