STEALTH Liposomal Irinotecan HCl (2.0mg/mL, 80-100nm)

STEALTH Liposomal Irinotecan HCl (2.0mg/mL, 80-100nm)

$979.00

PEGylated Liposomal Irinotecan HCl
Lipid composition: HSPC/CHOL/mPEG2000-DSPE (50:45:5 mol/mol)
Lipid concentration: 20.0 mM
Iroinotecan HCl: 2.0 mg/mL
Encapsulation efficiency: > 95% (typically 98%)
Loading battery: 250 mM ammonium sulfate
Mean particle size: 100 nm (80-110 nm)
External solution: 10% sucrose, 20 mM HEPES, pH 7.0
Shelf-life: 6 months, storage: 2-8 degree C

SKU: N/A Category:
SKUStock SIZE (ml) PriceQuantity
F30204-IT-2Yes2 ml $979.00
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Description

PEGylated Liposomal Irinotecan HCl

Irinotecan HCl is loaded into PEGylated liposomes composed of HSPC/CHOL/mPEG2000-DSPE (50:45:5 mol/mol) with ammonium gradient by the active loading approach. The liposomes are produced by the extrusion method. The product is of high quality with narrow particle size distribution and high drug encapsulation efficiency.

 

Product For Research only and NOT for Human Use

Specifications

Product code: F30204S-IT

Lipid composition:  HSPC/CHOL/mPEG2000-DSPE (50:45:5 mol/mol)

Lipid concentration:  20.0 mM

Iroinotecan HCl:  2.0 mg/mL

Encapsulation efficiency: > 95% (typically 98%)

Loading battery:  250 mM ammonium sulfate

Mean particle size:  100 nm (80-110 nm)

External solution:  10% sucrose, 20 Mm HEPES, pH 7.0

Shelf-life: 3 months, storage: 2-8 degree C

 

Irinotecan: Synonym: (S)​-​4,11-​diethyl-​3,4,12,14-​tetrahydro-​4-​hydroxy-​3,14-​dioxo-​1H-​pyrano[3′,4′:6,7]indolizino[1,2-b]quinolin-9-yl ester, CPT-11, [1,4′-Bipiperidine]-1′-carboxylic acid

CAS Number 100286-90-6, Empirical Formula: C33H38N4O6 · HCl, Sigma Cat# I1406

HSPC: hydrogenated phosphatidylcholine (Soy)

CHOL: cholesterol

mPEG2000-DSPE: 18:0 PEG2000 PE:1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000]

Additional information

SIZE (ml)

2 ml

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