ZM-336372, c-Raf inhibitor (TBI1030)
$108.00 – $396.00
c-Raf inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI1030-5MG | Yes | 5 MG | $108.00 | |||
TBI1030-25MG | Yes | 25 MG | $396.00 |
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Description
Product Details
Formal Name: 3-(Dimethylamino)-N-[3-[(4-hydroxybenzoyl)-amino]-4-methylphenyl]benzamide
Molecular Formula: C23H23N3O3
Formula Weight: 389.46
CAS Number: 208260-29-1
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 50 mg/ml).
Storage: -20°C
Stability: ≥ 2 years.
Applications
c-Raf inhibitor
Functions
Potent and specific inhibitor of the protein kinase c-Raf (IC50=70nM). Has no significant effect on many other protein kinases tested (even at 50µM) with the exception of p38 (SAPK2α) (IC50=2µM) and SAPK2β (p38β) (IC50=2µM). Induces a paradoxical >100-fold activation of c-Raf in whole cells. Induces apoptosis in a variety of cell lines. Cell permeable.
Application Procedures
First dissolved in DMSO (up to 50 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 1 month.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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