Xestospongin C, Inhibits IP3-mediated Ca2+ release (TBI1207)

Description

Product Details

Formal Name: Natural product isolated from the marine sponge Xestospongia sp.

Molecular Formula: C₂₈H₅₀N₂O₂

Formula Weight: 446.70

CAS Number: 88903-69-9

Purity: >97%

Formulation: Lyophilized

Solubility: Soluble in DMSO (up to 10 mg/ml)

Storage: -20°C

Stability: ≥ 2 years.

 

Applications

Inhibits IP3-mediated Ca2+ release

 

Functions

A potent and reversible inhibitor of IP3-mediated Ca2+ release, IC50 = 358 nM. Experiments with guinea-pig ileum permeabilized with alpha toxin revealed that Xestospongin C inhibits the IP3 receptor but not the ryanodine receptor in SR membranes. In intact smooth muscle cells it inhibits voltage-dependent Ca2+ and K+ currents at a concentration range similar to that at which it inhibits the IP3 receptor. It is a useful tool for probing the involvement of IP3 receptors in cellular signaling. Cell permeable.

 

Application Procedures

First dissolved in DMSO (up to 10 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 1 month.

 

Additional information

SIZE	10 ug, 50 µg

TBI1207_Xestospongin C