WY-14643, PPARα agonist (TBI1137)
$117.00 – $414.00
PPARα agonist
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI1137-50MG | Yes | 50 MG | $117.00 | |||
TBI1137-250MG | Yes | 250 MG | $414.00 |
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Description
Product Details
Formal Name: 4-Chloro-6-(2,3-xylidino)-2-pyrimidinylthioacetic acid
Alternate Names: Pirinixic acid
Molecular Formula: C14H14ClN2O2S
Formula Weight: 323.80
CAS Number: 50892-23-4
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 40 mg/ml).
Storage: RT
Stability: ≥ 2 years.
Applications
PPARa agonist
Functions
Selective PPARα agonist (EC50=0.63, 32 and >100 µM for PPARα,γ and δ, respectively). Displays anti-inflammatory activity and reduces LPS-induced inflammation in alveolar epithelial cells. Induces “browning” of white adipocytes in combined treatment with retinoic acid. Stimulates ADAM10-mediated proteolysis of amyloid precursor protein in a mouse model. Down regulates NFκB transcriptional activity. Review.
Application Procedures
First dissolved in DMSO (up to 40 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20°C for up to 6 months.
Additional information
SIZE (mg) | 250 MG, 50 MG |
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