Wiskostatin, N-WASP inhibitor (TBI1353)

Description

Product Details

Formal Name: 1-(3,6-Dibromocarbazol-9-yl)-3-dimethylaminopropan-2-ol

Molecular Formula: C₁₇H₁₈Br₂N₂O

Formula Weight: 426.15

CAS Number: 253449-04-6

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 30 mg/ml), or in Ethanol (up to 10 mg/ml).

Storage: RT

Stability: ≥ 2 years.

 

Applications

N-WASP inhibitor

 

Functions

A selective, reversible inhibitor of neural Wiskott-Aldrich syndrome protein (N-WASP) activity. Binds to the regulatory domain of N-WASP and inhibits activation of Arp2/3 complex by forcing N-WASP into an inactive conformation. Inhibits PIP2-induced actin polymerization (EC50=4 μM). Perturbs agrin-elicited acetylcholine receptor clustering. Inhibits the formation of dendritic spines and synapses in hippocampal neurons.

 

Application Procedures

First dissolved in DMSO (up to 30 mg/ml), or in Ethanol (up to 10 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.

Additional information

SIZE (mg)	25 MG, 5 MG

TBI1353_Wiskostatin