SKF-96365, TRPC channel blocker (TBI1068)
$117.00 – $468.00
TRPC channel blocker
SKU | Stock | SIZE (mg) | Price | Quantity | ||
---|---|---|---|---|---|---|
TBI1068-5MG | Yes | 5 MG | $117.00 | |||
TBI1068-25MG | Yes | 25 MG | $468.00 |
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Description
Product Details
Formal Name: 1-[2-(4-Methoxyphenyl)-2-[3-(4-methoxyphenyl)propoxy]ethyl]imidazole, hydrochloride
Molecular Formula: C22H26N2O3 ∙ HCl
Formula Weight: 402.90
CAS Number: 130495-35-1
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 20 mg/ml) or in Ethanol (up to 20 mg/ml).
Storage: -20°C
Stability: ≥ 1 year.
Applications
TRPC channel blocker
Functions
An inhibitor of receptor-mediated calcium entry (RMCE) with IC50‘s of 8.5 μM for ADP stimulated platelets and 11.7 μM for thrombin stimulated platelets. Also inhibits Voltage-gated Ca2+ but not ATP-gated Ca2+ entry. It has also been shown to block transient receptor potential canonical type (TRPC) channels, high-voltage-activated (HVA) L-type channels, K channels, sarcoplasmic reticulum Ca-ATPase and voltage-gated sodium channels. SKF-96365 is a potent blocker of LVA T-type Ca channels, in particular Ca(V)3.1 (IC50 = 0.56 μM).
Application Procedures
First dissolved in DMSO (up to 20 mg/ml) or in Ethanol (up to 20 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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