Safinamide, MAO-B inhibitor, Parkinson’s therapeutic (TBI2924)
$86.00 – $396.00
MAO-B inhibitor, Parkinson’s therapeutic
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI2924-5MG | Yes | 5 MG | $86.00 | |||
TBI2924-25MG | Yes | 25 MG | $396.00 |
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Description
Product Details
Formal Name: (S)-(+)-2-[[4-(3-Fluorobenzoxy)benzyl]amino]propenamide
Alternate Names: FCE-26743; PNU-151774E; NW-1015
Molecular Formula: C17H19F2N4O2
Formula Weight: 302.3
CAS Number: 133865-89-1
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 50 mg/ml)
Storage: -20°C
Stability: ≥ 2 years.
Applications
MAO-B inhibitor, Parkinson’s therapeutic
Functions
A selective and reversible inhibitor of monoamine oxidase B (MAO-B, IC50=98 nM with greater than 100-fold selectivity over MAO-A. Displays anticonvulsant activity and protects against kainate-induced seizures and hippocampal neurodegeneration in rat models. Reduces overactive glutamatergic signaling via use-dependent sodium channel blockade. A novel therapeutic for Parkinson’s disease with multiple modes of action. Effective as an add-on to dopamine agonist therapy in early Parkinson’s.
Application Procedures
First dissolved in DMSO (up to 50 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 2 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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