CPI-613, KGDH and PDH inhibitor; Anticancer activity (TBI3519)
$90.00 – $360.00
KGDH and PDH inhibitor; Anticancer activity
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI3519-5MG | Yes | 5 MG | $90.00 | |||
TBI3519-25MG | Yes | 25 MG | $360.00 |
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Description
Product Details
Formal Name: 6,8-bis(benzylthio-octanoic acid)
Alternate Names: Devimistat
Molecular Formula: C22H28O2S2
Formula Weight: 388.59
CAS Number: 95809-78-2
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 20 mg/ml)
Storage: -20°C
Stability: ≥ 2 years.
Applications
KGDH and PDH inhibitor; Anticancer activity
Functions
Lipoic acid analog which potently disrupts mitochondrial metabolism with selectivity for tumor cells in vitro and shows strong antitumor activity in vivo. Inhibits alpha-ketoglutarate dehydrogenase (KGDH) by a redox mechanisms selectively in tumor cells. Inhibits pyruvate dehydrogenase (PDH) as a mechanistically distinct, non-redox, effect. A novel anticancer agent with a mitochondria-targeted mode of action with non-genotoxic properties.. Has been used (along with PS48) to induce a Warburg-like metabolic state in fibroblasts. Combination treatment of CPI-613 and chloroquine inhibits the progression of clear cell sarcoma in a mouse model.
Application Procedures
First dissolved in DMSO (up to 30 mg/ml) or in Ethanol (up to 20 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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