Rucaparib phosphate, PARP inhibitor (TBI3321)
$126.00 – $504.00
PARP inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI3321-5MG | Yes | 5 MG | $126.00 | |||
TBI3321-25MG | Yes | 25 MG | $504.00 |
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Description
Product Details
Formal Name: 8-Fluoro-1,3,4,5-tetrahydro-2-[4-[(methylamino)methyl]phenyl]-6H-pyrrolo[4,3,2-ef][2]benzazepin-6-one
Alternate Names: AG-14699; PF01367338
Molecular Formula: C19H18FN3O ∙ H3PO4
Formula Weight: 421.36
CAS Number: 459868-92-9
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 25 mg/ml)
Storage: -20°C
Stability: ≥ 1 year.
Applications
PARP inhibitor
Functions
Rucaparib is a potent (Ki<5 nM) PARP1 inhibitor. Cytotoxic to human cancer cells or xenograft tumors with mutated or epigenetically silenced BRCA1/2. Demonstrates antiproliferative effects in 26 out of 39 ovarian cancer cell lines. Synergizes with other anticancer agents such as topotecan, carboplatin, doxorubicin, paclitaxel and temozolamide. Ameliorates the cardiotoxicity of doxorubicin. Recently approved for human use by the FDA.
Application Procedures
First dissolved in DMSO (up to 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20° for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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