Roxadustat, Prolyl hydroxylase domain inhibitor / HIF stabilizer (TBI4468)
$54.00 – $216.00
Prolyl hydroxylase domain inhibitor / HIF stabilizer
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI4468-5MG | Yes | 5 MG | $54.00 | |||
TBI4468-25MG | Yes | 25 MG | $216.00 |
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Description
Product Details
Formal Name: 2-[(4-Hydroxy-1-methyl-7-phenoxyisoquinoline-3-carbonyl)amino]acetic acid
Alternate Names: FG-4592
Molecular Formula: C19H16N2O5
Formula Weight: 352.35
CAS Number: 808118-40-3
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to at least 25 mg/ml)
Storage: -20°C
Stability: ≥ 1 year.
Applications
Prolyl hydroxylase domain inhibitor / HIF stabilizer
Functions
Pan-prolyl hydroxylase domain (PHD) inhibitor (IC50 for PHD2 = 591 nM) that stabilizes hypoxia-inducible factor (HIF) leading to erythropoiesis. Clinically useful for treatment of anemia related to chronic kidney disease. Accelerates cutaneous wound healing and shortens healing time via improvement in epidermal stem cell proliferation and motility and increasing angiogenesis. Displayed radioprotective effects in haematopoietic systems via up-regulation of HIF-1α, and against atherosclerosis via activation of adipose HIF-2α.
Application Procedures
First dissolved in DMSO (up to at least 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 2 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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