PF-4136309, CCR2 antagonist (TBI4261)
$135.00 – $522.00
CCR2 antagonist
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI4261-5MG | Yes | 5 MG | $135.00 | |||
TBI4261-25MG | Yes | 25 MG | $522.00 |
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Description
Product Details
Formal Name: N-[2-[(3S)-3-[[4-Hydroxy-4-(5-pyrimidin-2-ylpyridin-2-yl)cyclohexyl]amino]pyrrolidin-1-yl]-2-oxoethyl]-3-(trifluoromethyl)benzamide
Alternate Names: INCB8761
Molecular Formula: C29H31F3N6O3
Formula Weight: 568.60
CAS Number: 1341224-83-6
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to at least 25 mg/ml)
Storage: -20°C
Stability: ≥ 1 year.
Applications
CCR2 antagonist
Functions
PF-4136309 (1341224-83-6) is a potent (hIC50 = 5.2 nM, mIC50 = 13 nM, rIC50 = 17 nM) and selective inhibitor of CCR2. PF-4136309 significantly decreased inflammatory monocytes in a mouse model of pancreatic cancer. In combination therapy with the FOLFIRINOX regimen, PF-4136309 reversed immune suppression in the tumor microenvironment causing an influx of tumor infiltrating lymphocytes leading to overall enhanced efficacy in a phase 1b study.
Application Procedures
First dissolved in DMSO (up to at least 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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