PF-06835919, Ketohexokinase inhibitor (TBI3958)

Description

Product Details

Formal Name: 2-[(1R,5S)-3-[2-[(2S)-2-methylazetidin-1-yl]-6-(trifluoromethyl)pyrimidin-4-yl]-3-azabicyclo[3.1.0]hexan-6-yl]acetic acid

Molecular Formula: C₁₆H₁₉F₃N₄O₂

Formula Weight: 356.4

CAS Number: 2102501-84-6

Purity: >98%

Formulation: Powder

Solubility: Soluble in DMSO (10 mg/ml with warming)

Storage: -20°C

Stability: ≥ 2 years.

Applications

Ketohexokinase inhibitor

Functions

Potent (IC₅₀ = 10 nM KHK-C; 170 nM KHK-A) inhibitor of ketohexokinase (KHK), the first enzyme in the fructose metabolic cascade. It displayed high selectivity against other sugar kinases. Prevented hyperinsulinemia, hypertriglyceridemia, and hepatic steatosis in fructose-fed rats. The increased tumor proliferation effect of fructose in CaSki cells was inhibited by PF-06835919. An interesting new tool to study metabolic and fatty liver diseases.

Application Procedures

First dissolved in DMSO (10 mg/ml with warming), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.

Research use only.

Additional information

Datasheet:

TBI3958_PF-06835919_datasheet

MSDS:

TBI3958_PF-06835919_MSDS

Research use only.