PAC-1, Procaspase-3 activator (TBI2979)
$54.00 – $171.00
Procaspase-3 activator
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI2979-5MG | Yes | 5 MG | $54.00 | |||
TBI2979-25MG | Yes | 25 MG | $171.00 |
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Description
Product Details
Formal Name: 4-(Phenylmethyl)-1-piperazineacetic acid [[2-hydroxy-3-(2-propenyl)phenyl]-methylene]hydrazide
Molecular Formula: C23H28N4O2
Formula Weight: 392.49
CAS Number: 315183-21-2
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 35 mg/ml) or in Ethanol (up to 15 mg/ml)
Storage: -20°C
Stability: ≥ 1 year.
Applications
Procaspase-3 activator
Functions
PAC-1 is a procaspase-activating compound, directly activating procaspase-3, producing caspase-3, EC50=0.22 μM. It is less potent at activating procaspase-7, EC50=4.5 μM. It induces apoptosis in a variety of cancer cell lines. The mechanism of activation involves sequestering inhibitory zinc ions thus allowing procaspase-3 to autoactivate. Sensitizes cancer cells to various chemotherapeutic agents.
Application Procedures
First dissolved in DMSO (up to 35 mg/ml) or in Ethanol (up to 15 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol must be stored under inert gas at -80°C and will be stable for up to 2 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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