NH125, Eukaryotic elongation factor 2 (eEF-2) kinase inhibitor (TBI4840)
$117.00 – $396.00
Eukaryotic elongation factor 2 (eEF-2) kinase inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
---|---|---|---|---|---|---|
TBI4840-5MG | Yes | 5 MG | $117.00 | |||
TBI4840-25MG | Yes | 25 MG | $396.00 |
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Description
Product Details
Formal Name: 1-Hexadecyl-2-methyl-3-(phenylmethyl)-1H-imidazlium iodide
Molecular Formula: C27H45IN2
Formula Weight: 524.56
CAS Number: 278603-08-0
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to at least 25 mg/ml) or in Ethanol (up to at least 25 mg/ml)
Storage: -20°C
Stability: ≥ 1 year.
Applications
Eukaryotic elongation factor 2 (eEF-2) kinase inhibitor
Functions
NH125 was originally discovered as an antibacterial agent active against various Gram-positive and -negative bacteria via inhibition of histidine protein kinase. It was also found to be a potent inhibitor of eukaryotic elongation factor 2 (eEF-2) kinase (IC50 = 60 nM) with efficacy against a broad spectrum of human cancer cell lines. Other studies have linked the anticancer effects of NH125 to induction of eEF2 phosphorylation. NH125 has also been shown to engage the EIF2a-ATF4-CHOP axis resulting in induction of DR5 expression. Treatment of glioma stem cells with NH125 resulted in a sustained decrease in tumor volume via activation of integrated stress response (ISR) and GADD45 pathways.
Application Procedures
First dissolved in DMSO (up to at least 25 mg/ml) or in Ethanol (up to at least 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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