MZ1, BRD4 degrader (TBI5090)

Description

Product Details

Formal Name: (2S,4R)-1-((S)-2-(tert-Butyl)-17-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-4,16-dioxo-6,9,12-trioxa-3,15-diazaheptadecan-1-oyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

Molecular Formula: C₄₉H₆₀ClN₉O₈S₂

Formula Weight: 1002.6

CAS Number: 1797406-69-9

Purity: >98%

Formulation: Powder

Solubility: Soluble in DMSO (up to at least 100 mg/ml)

Storage: -20°C

Stability: ≥ 2 years

Applications

BRD4 degrader

Functions

MZ1 consists of JQ1 tethered to a ligand for the E3 ubiquitin ligase VHL and is a selective degrader of the BET bromodomain protein BRD4. It rapidly and potently induces reversible, long-lasting and unexpectedly selective degradation of BRD4 over BRD2 and BRD3. It exerts anticancer effects in acute myeloid leukemia by targeting c-Myc and ANP32B. An important tool for studying the effects of BRD4 degradation in cancer therapy.

Application Procedures

First dissolved in DMSO (up to at least 100 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 2 months.

Research use only.

Additional information

Datasheet:

TBI5090_MZ1_datasheet

MSDS:

TBI5090_MZ1_MSDS

Research use only.