ML-323, USP1-UAF1 inhibitor (TBI1560)
$144.00 – $576.00
USP1-UAF1 inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
---|---|---|---|---|---|---|
TBI1560-5MG | Yes | 5 MG | $144.00 | |||
TBI1560-25MG | Yes | 25 MG | $576.00 |
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Description
Product Details
Formal Name: N-(4-(1H-1,2,3-Triazol-1-yl(benzyl)-5-methyl-2-(2-isopropylphenyl)pyrimidin-4-amine
Alternate Names: CID 60167849; NCGC00262306
Molecular Formula: C23H24N6
Formula Weight: 384.48
CAS Number: 1572414-83-5
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 20 mg/ml)
Storage: -20°C
Stability: ≥ 1 year.
Applications
USP1-UAF1 inhibitor
Functions
Potent and reversible USP1-UAF1 deubiquitinase complex inhibitor with excellent selectivity against human DUBs, deSUMOylase, deneddylase and unrelated proteases, IC50=76 nm in a ubiquitin-rhodamine 110 assay. In H1299 non-small cell lung cancer cells treatment with ML323 dose dependently and robustly increased levels of monoubiquitinated PCNA compared to untreated cells at concentrations as low as 1 μM. It potentiates cisplatin cytotoxicity in non-small cell lung cancer and osteosarcoma cells. ML323 inhibition of upregulated USP1 in BRCA1-deficient tumor cells results in replication fork destabilization and decreased viability.
Application Procedures
First dissolved in DMSO (up to 40 mg/ml) or in Ethanol (up to 20 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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