Mirabegron, beta-3 Adrenergic agonist (TBI4228)

Description

Product Details

Formal Name: 2-(2-Amino-1,3-thiazol-4-yl)-N-[4-[2-[[(2R)-2-hydroxy-2-phenylethyl]amino]ethyl]phenyl]acetamide

Alternate Names: YM178

Molecular Formula: C₂₁H₂₄N₄O₂S

Formula Weight: 396.5

CAS Number: 223673-61-8

Purity: >98%

Formulation: Powder

Solubility: Soluble in DMSO (up to 40 mg/ml)

Storage: -20°C

Stability: ≥ 2 years.

Applications

beta-3 Adrenergic agonist

Functions

Mirabegron is a potent (EC₅₀ = 22.4 nM CHO cells expressing human ß3-ARs) beta-3 adrenergic receptor (ß3-AR) agonist with high selectivity over the beta-1 and beta-2 receptors. Clinically useful for the treatment of overactive bladder syndrome. Chronic treatment of human subjects with mirabegron increased brown adipose tissue (BAT) metabolic activity, increased HDL and bile acid levels, and produced substantial improvements in glucose and insulin metabolism. Mirabegron inhibited tumor growth in various tumor models including pancreatic ductal adenocarcinoma and hepatocellular carcinoma via altering global metabolism in an uncoupling protein 1 (UCP1; a key protein for non-shivering thermogenesis) dependent manner.

Application Procedures

First dissolved in DMSO (40 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.

Research use only.

Additional information

Datasheet:

TBI4228_Mirabegron_datasheet

MSDS:

TBI4228_Mirabegron_MSDS_2024

Research use only.