Lactoyl phenylalanine, Anorexigenic circulating metabolite (TBI5713)

Description

Product Details

Formal Name: N-[(2S)-2-hydroxy-1-oxopropyl]-L-phenylalanine

Alternate Names: Lac-Phe; N-lactoyl-phenylalanine

Molecular Formula: C₁₂H₁₅NO₄

Formula Weight: 237.3

CAS Number: 183241-73-8

Purity: >98%

Formulation: Powder

Solubility: Soluble in DMSO (at least 50 mg/ml)

Storage: -20°C

Stability: ≥ 2 years

Applications

Anorexigenic circulating metabolite

Functions

Exercise is associated with transient suppression of appetite which previously has been attributed to induction of appetite-regulatory hormone such as GLP-1 or the increase in circulating metabolites including L-lactate. A targeted metabolomics approach with blood samples from two independent human exercise studies resulted in the identification of N-lactoyl-phenylalanine (Lac-Phe) as a highly upregulated circulating metabolite following exercise. Lac-Phe was shown, using pharmacological and genetic methods, to be an exercise-inducible metabolite that suppresses feeding and obesity. A single injection of Lac-Phe was demonstrated to reduce food intake by ~50% in diet-induced obese mice. However, Lac-Phe is completely inactive when administered orally.

Application Procedures

First dissolved in DMSO (at least 50 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 2 months.

Research use only.

Additional information

Datasheet:

TBI5713_Lactoyl phenylalanine_datasheet

MSDS:

TBI5713_Lactoyl phenylalanine_MSDS

Research use only.