JNK-IN-8, JNK inhibitor (TBI5186)

Description

Product Details

Formal Name: 3-[[4-(Dimethylamino)-1-oxo-2-buten-1-yl]amino]-N-[3-methyl-4-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-benzamide

Alternate Names: JNK Inhibitor XVI

Molecular Formula: C₂₉H₂₉N₇O₂

Formula Weight: 507.6

CAS Number: 1410880-22-6

Purity: >98%

Formulation: Powder

Solubility: Soluble in DMSO (45 mg/ml)

Storage: -20°C

Stability: ≥ 2 years.

Applications

JNK inhibitor

Functions

Irreversible, specific JNK (c-Jun N-terminal Kinase) inhibitor (IC₅₀s = 4.67, 18.7, and 0.98 nM for JNK1, 2, and 3) that forms a covalent bond with a conserved cysteine in the ATP-binding site. Suppresses triple-negative breast cancer (TBNC) cell growth in vitro and in vivo through upregulation of lysosome biogenesis and autophagy. Suppresses inflammation and oxidative stress during LPS‑induced acute lung injury in mice. Alleviates cognitive impairment, neuroinflammation, and NLRP3 inflammasome activation in a rat model of acute respiratory distress syndrome (ARDS).

Application Procedures

First dissolved in DMSO (45 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.

Research use only.

Additional information

Datasheet:

TBI5186_JNK-IN-8_datasheet

MSDS:

TBI5186_JNK-IN-8_MSDS_2024

Research use only.