Jervine, Hedgehog inhibitor (TBI2388)
$153.00 – $612.00
Hedgehog inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI2388-5MG | Yes | 5 MG | $153.00 | |||
TBI2388-25MG | Yes | 25 MG | $612.00 |
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Description
Product Details
Formal Name: (3β,23β)-17,23-Epoxy-3-hydroxyveratraman-11-one
Alternate Names: 11-Ketocyclopamine
Molecular Formula: C27H39NO3
Formula Weight: 425.60
CAS Number: 469-59-0
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 5 mg/ml), in DMF (up to 6 mg/ml), or in Ethanol (up to 20 mg/ml).
Storage: -20°C
Stability: ≥ 2 years.
Applications
Hedgehog inhibitor
Functions
Inhibitor of Hedgehog signaling (IC50 = 0.5-0.7 µM). Binds directly to Smoothened (Smo). Inhibits the response of target tissues to Sonic hedgehog signaling. Induces COX-2 overexpression in human erythroleukemia cells.
Application Procedures
First dissolved in DMSO (up to 5 mg/ml), in DMF (up to 6 mg/ml), or in Ethanol (up to 20 mg/ml), then diluted to aqueous buffer. Solutions in DMSO, ethanol or DMF may be stored at -20° for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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